Martin Jeffrey Selected Research

Prion Diseases (Transmissible Spongiform Encephalopathies)

1/2017	Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein.
7/2015	Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian Prion.
6/2015	Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer's precursor protein (APP).
9/2014	Genotype-dependent molecular evolution of sheep bovine spongiform encephalopathy (BSE) prions in vitro affects their zoonotic potential.
1/2013	Membrane toxicity of abnormal prion protein in adrenal chromaffin cells of scrapie infected sheep.
11/2012	Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results.
4/2012	Disease phenotype in sheep after infection with cloned murine scrapie strains.
1/2012	Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy.
5/2011	Detection and localisation of PrP(Sc) in the liver of sheep infected with scrapie and bovine spongiform encephalopathy.
1/2011	Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease.

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Martin Jeffrey Research Topics

Disease

36	Scrapie 01/2021 - 02/2002
25	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2017 - 04/2003
17	Infections 01/2021 - 05/2002
16	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2021 - 05/2003
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 02/2002
4	Alzheimer Disease (Alzheimer's Disease) 06/2015 - 03/2010
2	Amyloid Plaque 10/2016 - 12/2013
2	Amyloidosis 06/2015 - 12/2010
2	Brain Diseases (Brain Disorder) 01/2015 - 03/2010
2	Chronic Wasting Disease 02/2010 - 03/2008
2	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2010 - 07/2006
1	Coinfection 01/2021
1	Proteostasis Deficiencies 10/2016
1	Sheep Diseases (Sheep Disease) 01/2011
1	Gliosis 01/2011
1	Trypanosomiasis 12/2010
1	Multiple Sclerosis 12/2010
1	Autoimmune Diseases of the Nervous System 12/2010
1	Sepsis (Septicemia) 12/2010
1	Fatal Familial Insomnia 01/2010
1	Gerstmann-Straussler-Scheinker Disease 01/2010
1	Kuru 01/2010
1	Nervous System Diseases (Neurological Disorders) 12/2009
1	Weight Loss (Weight Reduction) 04/2008

Drug/Important Bio-Agent (IBA)

38	Prion ProteinsIBA 01/2017 - 02/2002
21	Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugateIBA 06/2015 - 04/2003
13	PrionsIBA 01/2021 - 02/2002
5	Codon (Codons)IBA 01/2016 - 07/2003
5	Peptide Hydrolases (Proteases)FDA Link 11/2012 - 04/2004
5	PrPSc ProteinsIBA 11/2012 - 05/2003
4	Amyloid (Amyloid Fibrils)IBA 01/2017 - 03/2010
4	Proteins (Proteins, Gene)FDA Link 10/2016 - 07/2006
3	bone mealIBA 10/2015 - 03/2009
3	Peptides (Polypeptides)IBA 06/2015 - 04/2003
2	Methionine (L-Methionine)FDA Link 01/2016 - 11/2009
2	Alanine (L-Alanine)FDA Link 01/2014 - 07/2003
2	AntibodiesIBA 07/2010 - 05/2003
2	AntigensIBA 03/2008 - 12/2007
1	Threonine (L-Threonine)FDA Link 01/2016
1	Membrane Proteins (Integral Membrane Proteins)IBA 06/2015
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2015
1	Arginine (L-Arginine)FDA Link 01/2014
1	Biomarkers (Surrogate Marker)IBA 11/2012
1	Antigen-Antibody Complex (Immune Complex)IBA 12/2009
1	Isoleucine (L-Isoleucine)FDA Link 11/2009
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 09/2009
1	Indicators and Reagents (Reagents)IBA 04/2008
1	EnzymesIBA 03/2008
1	antineoplaston A10 (A 10)IBA 02/2007
1	AldehydesIBA 07/2003
1	Amino Acids FDA Link 04/2003
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 05/2002
1	Protein Isoforms (Isoforms)IBA 02/2002

Therapy/Procedure

2	Blood Transfusion (Blood Transfusions) 12/2008 - 07/2006
1	Intraperitoneal Injections 05/2002